- Los Angeles Chargers 24–27 Kansas City Chiefs
- Justin Herbert hampered after suffering apparent rib injury
Patrick Mahomes threw two touchdown passes, rookie Jaylen Watson returned an interception 99 yards for the go-ahead fourth-quarter score, and the Kansas City Chiefs held on to beat the Los Angeles Chargers 27-24 on Thursday night.
Mahomes finished with 235 yards passing, and Jerick McKinnon and Justin Watson hauled in the TD passes for the Chiefs (2-0), who fell behind 10-0 in the first quarter and spent most of the game playing catch-up.
