- San Francisco 49ers 38-10 Arizona Cardinals
- Niners move to 6-4; Cardinals fall to 4-7
Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by blowing past the Arizona Cardinals 38-10 on Monday night in Mexico City.
It was the fifth regular-season NFL game played in Mexico City and the first since 2019. Technically a Cardinals home game, the raucous announced crowd of 78,427 fans at Estadio Azteca heavily favored the 49ers, roaring particularly loud when Kittle and Deebo Samuel scored.
